At The Gates Of Translational Medicine 

EPIGENETICS AND

TRANSLATIONAL MEDICINE 

 info@epigenetica.org 

fabiocelnikier@gmail.com 

Much has been written about the impact of the environment and its early links, especially the social atmosphere and then, as factors conducive to a healthy psychophysical development or vulnerable, and as factors that facilitated the expression of genetic predispositions or chronic hyperactivation adquiridas. La of certain circuit generates a hypersensitivity to reactivate these responses to future stimuli. This past experience will act as facilitators of subsequent responses. Chronic adverse early experiences, generate an allostatic load of abuse of allostasis systems and a “vulnerable phenotype CRH” with facilitating the expression of this gene and hypersensitivity of the axis-Pituitary-Adrenal Hipolálamo. 

Our concepts about the inheritance given a tremendous shift.

The dark areas of this discipline are beginning to be clarified. And this has a direct impact on how we conceive of and understand the world. We will be finding the balance between the humanistic sense of our daily work and expertise that give us more amazing genetics, epigenetics, proteomics and psiconeuroinmunoendocrinología.Iremos know the deep sense of humanity from a multilevel perspective unexpected.

 

Epigenetics BASICS

 

And so we understand, among many things, transcendence trans. We will learn about the legacy of our genes from our grandparents to us and from us to our children and grandchildren as we never received. And then understand that human transcendence is multidimensional, not just a metaphor, a hope, or limited to the philosophical question or psicológico.Esto give us data to work with the person both medicine and psychotherapy from other new perspectives.Psychotherapists can not ignore all this knowledge and yet we know the challenge of integrating our best ser.Hace for some years yet, it could matter little to a psychologist the discovery of a doctor in the area of neuroscience. Not even knowing that that physician had made the Nobel in your area. I could feel our patients ajeno.Tanto offices of psychotherapists who can link the word integrative therapy with neuroplasticity, the latter with chromatin changes, and then travel to memory and learning new lifestyles. And that change in ambioma again, and circular form, we will change the ways of learning. Spiritual and biological.

 

  TRANSLATIONAL MEDICINE 

Translational medicine is for the application model in which new discoveries targeted clinical and biomedical research relevant to human disease related to both improved diagnosis, treatment, prognosis and prevention of diseases, such as to answer scientific questions arising from daily clinical practice.Translational Medicine supports clinical researchers to identify by direct observations, new hypotheses relevant alternatives and impacts of the disease to improve the health of patients and therefore public health. It is the updated version of evidence based medicine, with the integrated application of new tools in genomics, proteomics, pharmacology, biomarkers, designs, methods and technologies that increase the clinical pathophysiologic understanding of disease.It is an emerging paradigm of medical practice and interventional epidemiology, and is based on the process of translational research. The combination of patient-oriented basic research, together with preclinical and clinical research is called translational research. Translational research is one of the most important in modern medicine has improved clinical practice, one of his main examples are the benefits achieved from the application of stem cells (stem cells).(Victor Manuel Valdespino-Gómez)

 

In this video you can see some of its aspects

 In principle, and to clarify a classic question of evolutionists, epigenetics is what helps explain why humans and chimpanzees are so different in their complexity if, as you know, share 99% of the genes.

When we speak of epigenetic phenomena that we refer to do not affect the DNA sequence of genes but which vary in expression.

It is the inheritance of expression patterns of genes that are not determined by the genetic sequence (the string of base pairs of DNA from each individual).

And this heritage is fixed alternative because the genes are expressed or not depending on certain biochemical conditions as the methylation of DNA or histones, or the form of chromatin, and other causes not yet known.

DNA methylation - A fundamental epigenetic mechanism

A nice metaphor for fashion, describes the devices are epigenetic biochemical dresses bearing the naked DNA. If these garments are thin and transparent, then you can see the DNA and genes can be expressed. If instead, these robes are thick, do not give a DNA and express the genes do not stop. 

Epigenesis be defined, using terms of fashion, by reversible DNA changes (like putting on a leather coat or a casual transparency) that make some genes are expressed or not depending on external conditions.

      Epigenome And Ambioma: Epigenetics is the speaker of the environment with genetics.

This explains the action of lifestyle on the genes.

Diseases should then genetic and epigenetic alterations.

An example of interaction between the epigenome and ambioma: In cardiovascular disease, the formation of plaque is due to three important factors:

1-A genetic susceptibility

2-A diet high in fat,

3-And the existence of epigenetic patterns of gene expression that allow fats hurt.

Epigenesis: epigenetic variations control the activity of genes. If high concentration of “X” substance, the activity will be high. The epigenetic code comprises a system of molecules bound to the DNA or histones, and governs the expression of genes for protein tails (those of histones) catalyze a wide variety of chemical additions, such as neighboring genes that amplify acetyl. 

Epigenetic inheritance is the transmission of information sequences non-DNA through meiosis or mitosis.

The epigenetic information modulates the expression of genes without altering the DNA sequence. And it does so through different mechanisms. 

The most studied are today:

1-The DNA methylation patterns are best studied and understood as markers of epigenetic phenomena. Cytosine methylation of DNA: A DNA modification in which a methyl group is transferred from S-adenosylmethionine to C-5 position by a DNA cytosine-5 metiltrasferasa.DNA methylation occurs almost exclusively in CpG dinucleotides, having an important role in regulating gene expression. 

2-genomic imprinting (Genomic Imprinting).

3-Modification of histones: including acetylation, methylation and phosphorylation.

Epigenetics refers to, then any mechanism that uses a body to pass hereditary information from one generation to another.

IMPRINTING: When we speak of Imprinting, we refer to genes that can modify its operation without a change in DNA sequence.

“This change in their presentation that they have genes” Imprint “is usually linked to their parental origin.

“An imprinted gene is expressed in a way that its origin is paternal and the other when it comes from maternal gamete.

“It seems that there is a cellular mechanism that somehow” mark “or leave an imprint on all genes” Imprint “according to the sex of the individual.

“This means that all imprinted genes and their alleles of each gene will have a paternal imprinting if they come from a man. Similarly happen to those genes from a woman, the mother is imprinting. 

We have therefore a genetic code, but also an epigenetic code, consisting of a system of molecules bound to the complex DNA / chromatin structure that govern the expression of genes.

Protein tails of the histone catalyze a wide variety of chemical mechanisms such as acetylation and methylation, which amplify the expression of neighboring genes. The DNA methylation patterns are best studied and understood as markers of epigenetic phenomena. 

Genotype and Phenotype: Genotype is a framework within which they can express many possible phenotypes, and the development of these phenotypes is epigenic.

If you are exposed to toxins produced in you epimutations, you can upload those changes to your children, grandchildren and great grandchildren. You are responsible and guardian of your genome. 

Epigenetic development, then, involves an enrichment of genetic information, and such enrichment occurs from the outside environment (ambioma), and this applies to both health and in pathological situations.

And if the genetic influences on behavior and behavior genetics, causality is a circular phenomenon. And trans. 

 Epigenetik

Epigenetics

פּעראַדיים עפּאַדזשאַנעטיק

epigenetische

Парадигма епигенетичен

Epigeneticsepigenetske

EpigenetickýPeriytyminen

Epigeneettinen

Επιγενετική

Epigenetikk

Epigenetyka

 הפרדיגמה ההתווצרותי

Epigenetika

 

 “Your beliefs become thoughts …

Your thoughts become your words …

Your words become your actions …

Your actions become your habits …

Your habits become your values …

Your values become your destiny …“

(Gandhi) 

 

 

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fabiocelnikier@gmail.com